The effect of aspirin on preeclampsia and fetal growth restriction (FGR) in obese pregnant women : a randomized controlled clinical trial

Background: To evaluate the effect of aspirin on preeclampsia and fetal growth restriction (FGR) in obese pregnant women. Methods: A randomized clinical trial with 187 participants. Participants were allocated to either an intervention (aspirin; n=89) or control (placebo; n=98) group. In two groups, intervention was done from 13-20 until 34 weeks of pregnancy. Outcomes were preeclampsia and FGR. Data were analyses were analyzed using x2. Results: The results of this study show that preeclampsia (1.1 vs. 11.2; P<0.05) and FGR (3.4 vs. 21.4; P<0.001) were significantly lower in intervention compared with the control group. Conclusion: The results of this study showed that administration of aspirin at 13- 20 weeks of pregnancy in obese women can decrease the incidence of preeclampsia and FGR. Therefore, in high risk people with obesity early in pregnancy, it can be used for prevention of preeclampsia and consequently FGR.